Los Blancos failed to get over Real Betis in Andalusia and fell behind Barcelona in the race for bragging rights in Spanish top flight football.
Benito Villamarin saw Real Betis triumph over Real Madrid in a tightly contested affair. Sidnei gave the hosts the lead before Karim Benzema clawed one back and levelled the fixture deep into first half injury time.
The second half saw the Seville giants go close through Joaquin but Los Blancos stood firm. However, nine minutes from time, a misplaced Benzema pass saw an end to Madrid’s resilience. Cristian Tello ran through the Madrid defense to score the winner.
It was curtains for the Spanish giants and also looks likely to end their title aspirations.