Manchester United are at the top of Group A, with a maximum of points after three rounds, while their visitors today have no points.
Flashscore presents the key facts before the match:
Manchester United are unbeaten in the home European group stage games since a defeat to Cluj in the 2012-13 Champions League (CL).
Benfica arrive at Old Trafford with a poor recent defensive away record in European games. They have conceded 4+ goals in 3 of their last 4 European away games.
In a record stretching back to February 1966, United’s home record against Benfica reads: W3, D1, L0. The aggregate score from those games is United 10-8 Benfica.
Overall, United’s record against Portuguese opposition in European competition is W15, D5, L3 – although two of the defeats were by 4+ goals!
It was against Benfica that Manchester United won its first ever top-level European cup, with a 4-1 win in May 1968.
Benfica’s all-time record against English opposition is W9, D6, L16.
If translated into a league for points per game against English opponents, Benfica have the second best record of the ‘big three’ Portuguese teams: 1.06 per game compared to Sporting Lisbon’s 1.33.
Clean sheets are a common occurrence for United in CL group games at Old Trafford. The last two CL group stages have seen United keep 2 clean sheets out of 3.
Manchester United: M. Carrick (injury), M. Fellaini (knee injury), Z. Ibrahimovic (knee injury), P. Pogba (muscle injury), M. Rojo (knee injury)
Benfica: A. Almeida (red card), Luisao (red card), Jardel (doubtful), D. Pereira (ankle injury).