4. FC Barcelona – 13/2 (7.5)
A lot has changed over at Barcelona ever since they secured the top spot in Group F by four points from Borussia Dortmund.
The Catalan giants have replaced manager Ernesto Valverde with Quique Setien, who has never coached a club in the UEFA Champions League. His lack of experience could prove costly at such a critical time.
Although Setien remains unbeaten in his opening eight games in charge, with six wins and two draws. It’s nothing special for a big club like Barcelona, but it’s a respectable start at least.
How the Blaugrana will fare in the knockout stages, though, will be Setien’s true challenge. After those humiliating semi-final exits to Liverpool and AS Roma, only the title will be good enough.
Barcelona’s hopes will probably all hinge on six-time Ballon d’Or winner Lionel Messi once again.